Disturbed dopamine system: new findings on FCD type 2 and epilepsy

How disturbed signal paths could favor epileptic seizures - University of Bonn

Research at the University of Bonn illuminates decisive relationships between the dopaminergic system and the development of epileptic seizures, especially in patients with focal cortexdysplasia (FCD) type 2. Dopamine, a significant neurotransmitter in the human brain, plays a central role in regulating attention, learning and the excitability of neural networks. A current study has shown that the distribution and function of the dopaminergic system in the affected brain regions at FCD could be significantly changed.

The research results indicate that excessive expression of certain dopamine receptors in the neurons, which are closely connected to the disease process at FCD. Norisa Meli, a doctoral student at the Institute for Reconstructive Neurobiology of the UKB and first author of the study, emphasizes that these deviations may contribute to the development of epileptic seizures. In addition, they could explain why many sufferers also suffer from difficulties in concentration and mood.

In the studies, it is emphasized that dopamine plays an important role in the modulation of neuronal networks, especially when developing in the cortex. Prof. Sandra Blaess, a leading researcher at the UKB, emphasizes that understanding the disturbed dopamine modulation in FCD type 2 is a relatively unexplored area that may open new perspectives on the disease mechanisms

The study combines detailed molecular analyzes of human tissue samples with preclinical models in mice that map the genetic changes in FCD type 2. Prof. Albert Becker, a leading expert in cellular neurosciences, emphasizes that these new knowledge expand the understanding of the complex neuropathology of dysplasia and offer valuable information for new therapy approaches that go beyond the control of seizures.

In the long term, researchers strive to support the development of the development of more targeted and effective treatment methods for patients with FCD. These developments could not only improve the quality of life of those affected, but also open up new ways for the therapy of epilepsy.