New models for the defense cells in the lungs: a research outlook

Transdisciplinary Research Award for Mathematicians and Biochemist - University of Bonn

The University of Bonn has launched a research prize that promotes transdisciplinary cooperation between mathematics, computer science, medicine and life sciences. The price is endowed with up to 100,000 euros and is aimed at research teams that pursue innovative approaches to better understand complex life systems. These initiatives aim to develop new strategies to improve health and to research the mechanisms of complex systems.

The winners, Jun.-Prof. Dr. Ana Ivonne Vazquez Armendariz and Prof. Dr. Jan Hasenauer, are honored for their work to investigate alveolar macrophages. These feed cells play a central role in the lung's immune system by being responsible for the defense against pathogens. The research of the two scientists focuses on the analysis of the movement behavior of these cells, which is examined by a mathematical model in combination with experiments on adapted 3D organoids.

The alveolar macrophages have different origins, which could have an impact on their function in lung tissue. The scientists use this findings to clarify whether the cells act in the lungs in a targeted manner or by chance. Your approach combines innovative biochemical research methods with mathematical models in order to better understand the motion dynamics and to develop possible therapeutic approaches.

The initiative for the awarding of the transdisciplinary research price is part of the "Life and Health" research area at the University of Bonn. An interdisciplinary dialogue is encouraged there, which is of central importance for the future of the development of knowledge in the life sciences. The close cooperation between the areas of mathematics and biosciences is becoming increasingly important in order to cope with the challenges of complex health issues.

The recognition of the award winners is also a reflection of their previous scientific achievements. Ana Ivonne Vazquez-Arrendariz has already further developed her research on lung organoids from Mexico about Germany and will now continue her innovative work at the University of Bonn. Jan Hasenauer contributes extensive experiences in engineering and life science to research and makes a decisive contribution to combining these disciplines. Joint research promises to gain new insights into the immunology and pathophysiology of the lungs.