Revolutionary discovery: New patho blocker stops Salmonella early!

Revolutionary discovery: New patho blocker stops Salmonella early!

Tübingen, Deutschland - A research team of the University of Tübingen and the German Center for Infection research has discovered a new substance called C26 that has the potential to stop salmonella infections early. This patho blocker could be of crucial importance for both people and animals, since salmonella, which are typically transmitted via contaminated foods, are responsible for serious gastrointestinal inflammation.

The newly discovered substance C26 inhibits the key mechanisms that Salmonella need to penetrate in cells of the gastrointestinal tract. For this purpose, the bacteria inject effector proteins into the cells, which can cause inflammation and systemic infections. The results of this research were recently published in the journal Science Advances . This publication emphasizes the urgent need for alternative treatment options, since Salmonella has developed resistance to many antibiotics in the past.

functionality of C26

C26 works by specifically disturbing the Salmonella signal chains during the infection process. In particular, the substance fits into the binding site of the Hild regulator, which plays a central role in the cell invasion of the bacteria. This interaction interruptes the function of Hild before the bacteria can penetrate the tissue. This early intervention option makes C26 a promising option to impair the pathogenicity of salmonella and its ability to hide in macrophages, to reduce as the researchers explain in detail.

The specific effect of C26 on Salmonella has the advantage that the human microbioma is not negatively influenced. This is particularly important in view of the current challenges with antibiotic resistance. An increasing problem is due to the increasing resistance of Salmonella tribes against common antibiotics such as ampicillin and ciprofloxacin. According to Research results there is an increase in antibiotic resistance in Salmonella strains by 20–30% per decade.

outlook for further development

The discovery of the Pathoblock C26 marks a promising step in combating salmonella infections. Future research is necessary to further develop C26 and similar substances. In particular, the application in veterinary medicine, especially in poultry, is considered promising. In view of the challenges associated with salmonella control and the increase in resistance, the development of pathoblockers such as C26 could be decisive in order to address humanitarian and veterinary problems.

The combination of innovative therapeutic approaches with a deep understanding of the biological mechanisms behind Salmonella is the key to improving health strategies in the present and future.