Revolutionary RNA therapies: Hope for people with liver in Lower Saxony!

Revolutionary RNA therapies: Hope for people with liver in Lower Saxony!

Research on the treatment of liver diseases receives a decisive thrust from Boehringer Ingelheim Foundation, which provides funding with 600,000 euros. The funds are intended for innovative basic research at the Hannover Medical School (MHH), which was made by Professor Dr. Amar Deep Sharma is managed. Sharma and his team are working on using therapeutic RNA as a possibility to heal liver fibrosis and metabolic fatty hepatitis (mash). These diseases affect millions of people and lead to almost 300,000 deaths in Europe every year, as the MHH reports in a current report ( mhh ).

The causes of liver diseases are diverse and include chronic liver damage caused by fatty liver diseases and fibrosis. In particular, liver -related mortality increases exponentially with advancing fibrosis. According to source, progress on cirrhosis can have dramatic effects on mortality and incidence of hepatocellular carcinoma ( Pubmed ).

The role of the RNA in therapy

Medical research increasingly relies on RNA-based therapeutic agents to develop new medication. Professor Sharma has already made significant progress through the application of an MRNA that contains the construction plan for the Hepatocyte core factor 4 Alpha (HFN4α). HFN4α is a central key factor in the liver metabolism; However, its mirror drops when fibrosis progresses. The team has shown that therapeutic mRNA can restore the HFN4α level and reduce liver damage.

In addition, Sharma is planning to research other MRNA therapy candidates and non-encoding RASE to support the regeneration of the liver tissue. The accumulation of collagen and muscle proteins in the extracellular matrix, caused by myofibroblasts, plays a crucial role in the development of fibrosis. Sharma and his colleagues already have three new potential regulators of the fibropes and want to examine their therapeutic potential more precisely ().

health -promoting measures

In addition to the latest therapeutic approaches, preventive measures to improve liver health are also important. Nutrition experts recommend a moderate calorie intake without special diets combined with the reduction of carbohydrates and saturated fatty acids. A Mediterranean diet that is rich in vegetable food and healthy fats can also contribute to improving the liver values. Particularly noteworthy is the positive influence of coffee consumption, which is considered a hepatoprotective and can lower the risk of liver cirrhosis and hepatocellular carcinoma ( The pta ).

Overall, the current research at the MHH shows that therapeutic RNA potential has for the treatment of liver diseases, while preventive measures and healthy lifestyle decisions play an important role in dealing with these diseases.