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Breakthrough in Cologne: Immunotherapy could stop visual loss in diabetes!
New research approaches to immune modulation in diabetic retinopathy at the Cologne University Hospital promise innovative therapies.
Breakthrough in Cologne: Immunotherapy could stop visual loss in diabetes!
The eyes are our window to the world, and for those affected by diabetes, this window can quickly become cloudy. A new study led by the Chair of Experimental Immunology of the Eye at the University Hospital of Cologne and the Medical Faculty highlights innovative approaches to the treatment of diabetic retinopathy (DR). This disease is one of the most common microvascular complications of diabetes and could potentially be approached in a very different way in the future than has previously been the case. The Cologne University Hospital reports on progress in research under the direction of Univ.-Prof. Dr. Thomas Langman.
Diabetic retinopathy occurs in 25% to 27% of people with type 1 diabetes and 9% to 16% of type 2 diabetics. This disease can lead to irreversible eye damage and is often accompanied by other eye diseases such as diabetic macular edema or even cataracts DiabetesDE. The current study examines a less conventional perspective: instead of only taking blood vessels into focus, immune cells, such as macrophages and microglia cells, are also considered that play a role in the development of the disease.
New ways in treatment
According to the study, published in the journal JCI Insight, it appears that inflammatory reactions in the retina are largely responsible for the development of DR. Dr. Urbanus Kinuthia and his team have developed medical models in mice that simulate the effects of pericyte depletion or a lack of PDGFB. These interventions caused persistent inflammation and reactivity of microglial cells. Interestingly, targeted pharmaceutical intervention was able to reverse the damage to the retina, representing a potential paradigm shift in the treatment of DR PMC.
Early immune modulation could thus be a load -bearing pillar in the therapy of diabetics with loss of vision. The aim remains the development of new treatment strategies that not only relieve the symptoms, but also slow down the progression of the disease. This could be particularly important for the estimated 3.5 million people in Germany who are affected by diabetes and their risk of eye damage increases due to the satisfaction of their illness.
Regular checks are essential
The study highlights the importance of regular ophthalmological check-ups to detect early signs of the disease. Many sufferers who do not experience any symptoms often forego necessary examinations. The risk of missing important warning signs such as blurred vision or dark spots in the field of vision is enormous warns DiabetesDE.
If advances in research are to reach those affected, a rethink is necessary. We must all raise awareness of the importance of preventive healthcare and controlling risk factors such as blood sugar, blood pressure and cholesterol levels. After all, a healthy eye is an essential part of quality of life!